Tuesday, August 6, 2019
Academic performance and technology Essay Example for Free
Academic performance and technology Essay Space exploration is the discovery and exploration of outer space by means of space technology. Physical exploration of space is conducted both by human spaceflights and by robotic spacecraft. While the observation of objects in space, known as astronomy, predates reliable recorded history, it was the development of large and relatively efficient rockets during the early 20th century that allowed physical space exploration to become a reality. Common rationales for exploring space include advancing scientific research, uniting different nations, ensuring the future survival of humanity and developing military and strategic advantages against other countries. Space exploration has often been used as a proxy competition for geopolitical rivalries such as the Cold War. The early era of space exploration was driven by a Space Race between the Soviet Union and the United States, the launch of the first man-made object to orbit the Earth, the USSRs Sputnik 1, on 4 October 1957, and the first Moon landing by the American Apollo 11 craft on 20 July 1969 are often taken as the boundaries for this initial period. See more: Recruitment and selection process essay The Soviet space program achieved many of the first milestones, including the first living being in orbit in 1957, the first human spaceflight (Yuri Gagarin aboard Vostok 1) in 1961, the first spacewalk (by Aleksei Leonov) on 18 March 1965, the first automatic landing on another celestial body in 1966, and the launch of the first space station (Salyut 1) in 1971. After the first 20 years of exploration, focus shifted from one-off flights to renewable hardware, such as the Space Shuttle program, and from competition to cooperation as with the International Space Station (ISS). With the substantial completion of the ISS following STS-133 in March 2011, plans for space exploration by the USA remain in flux. Constellation, a Bush Administration program for a return to the Moon by 2020 was judged inadequately funded and unrealistic by an expert review panel reporting in 2009. The Obama Administration proposed a revision of Constellation in 2010 to focus on the development of the capability for crewed missions beyond low earth orbit (LEO), envisioning extending the operation of the ISS beyond 2020, transferring the development of launch vehicles for human crews from NASA to the private sector, and developing technology to enable missions to beyond LEO, such as Earth/Moon L1, the Moon, Earth/Sun L2, near-earth asteroids, and Phobos or Mars orbit.[5] As of March 2011, the US Senate and House of Representatives are still working towards a compromise NASA funding bill, which will probably terminate Constellation and fund development of a heavy lift launch vehicle (HLLV).[6] In the 2000s, the Peoples Republic of China initiated a successful manned spaceflight program, while the European Union, Japan, and India have also planned future manned space missions. China, Russia, Japan, and India have advocated manned missions to the Moon during the 21st century, while the European Union has advocated manned missions to both the Moon and Mars during the 21st century. From the 1990s onwards, private interests began promoting space tourism and then private space exploration of the Moon (see Google Lunar X Prize). Benefits of this to Mankind There are critics who disagree with the expenditure on space exploration, which they claim can better be used to solve earthly problems. However, they seem to forget that this is one of the fields which tests a mans intellect. But, how does a common man draw benefits of space exploration? The advances made in field of space exploration can be well used in other fields such as medicine, agriculture, etc. The following is the list of benefits of space exploration to mankind: Global Positioning System: The mankind depends on the sea trade for transportation of food grains, fossil fuels, metal ores, etc. Global navigation system, GPS helps in timely delivery of these essential goods by providing the ships with essential navigation information. The GNS services are made available using networks of satellites which also enables satellite Internet and satellite phones. Weather Forecast and Agriculture: Gone are the days, when we used to take an umbrella with us while going out if there were black clouds in the sky. Now we can rely on the weather reports updated on an hourly basis. The accurate weather forecast is possible only because of the satellites in the space. The satellites also help us in predicting the crop yields, pest infestation and the area under cultivation. Natural Calamities: It is easy to predict natural calamities such as floods, storms, tornadoes, hurricanes and to locate wildfires and their extent with the help of satellites. Minerals and Mining: Minerals buried deep under the Earths surface can be located using satellites. Precious fossil fuels can be found with the help of satellites. Electronics: The field of electronics and computers have also benefited from the space exploration. The astronauts have manufactured miniature electronic parts that could only be produced in the space during their experiments in the space stations and space shuttles. Asteroids: It is believed that an asteroid strike eliminated the dinosaurs on the Earth. One of the benefits of space exploration is that we know about the thousands of asteroids and we can also be vigilant about their drifts. May be we could prevent dinosaurian death of mankind, if and when an asteroid is positioned to repeat history. If it happens, it would be because of the knowledge which is the direct benefit of space exploration. Energy Source: The scientists and researchers all over the world are attempting to harness the power of nuclear fusion. The process which enables the Sun to produce energy in abundance. It is believed that quantity of electricity generated using 1kg of hydrogen would be equivalent to that of 11,000 metric tons of coal. Medicine: Another field to glean the benefits of the satellite exploration is that of medicine. Metal alloys that are manufactured to be used in spacecraft and space shuttles are also used in the health care industry. Nitinol, an alloy is used to make braces. The miniature electronic components which were developed for the space program can be used in electronic pain-control device that some patients need to use. The implantable insulin pump is based on the mechanical robot arm developed for the Mars Voyager probe. The space exploration benefits also encompasses the field of communication which needs no explanation. The applications of knowledge and the technologies, that are the outcome of the mans efforts to explore space, are making his life easier indeed!
Monday, August 5, 2019
Understanding Child Development through Observation
Understanding Child Development through Observation Introduction: Background For observing and evaluating the child development, an online site is accessed where a nursery video is available and in the video the child that I chose to observe is a four year old girl that I will refer to as Amani. She is highly intelligent and confident child; not only has this she had extraordinary skills to socially move around independently. I observe Amani in the school classroom; play area and garden area where she has been involved in different activity. This observation has been conducted between 9.23am until 11.09am of all her activities. The objective of this observation is to make the progressive note of the childs physical, intellectual, emotional, linguistic and social development. In the next section there is description of observation and followed by the evaluation and childs profile. Observation Description Amani stands near to table on which there are name tags of students, she leans to pick her names tag with a little hesitance and picks the tag and pastes it on the name board. During the time she has smile on her face and looks pleased with this activity. Later on she is in her classroom sitting on floor along with her all classmates, she is smiling and has her eyes on her teacher, and paying attention to what teacher is saying intently. She is constantly smiling and moving her body in swinging way. Now, teacher is singing a poem Mary and Amani is singing along with the teacher and continuously smiling with pleasure. Teacher is reading the students story about growing flower plants, teacher speaks of flower planting, that there are some seeds and Maule! You will plant them and they will grow into a beautifulà ¢Ã¢â ¬Ã ¦flower Amani says flower with the teacher. Teacher says Maule! What do you think that seeds are going to needà ¢Ã¢â ¬Ã ¦ soilà ¢Ã¢â ¬Ã ¦ andà ¢Ã¢â ¬Ã ¦ Amani cheerfully speaks waterà ¢Ã¢â ¬Ã ¦ waterà ¢Ã¢â ¬Ã ¦ making herself to be heard. Teacher says that you can go and play and Amani raises her hand cheerfully turns back and forth to her classmates and she walks around touching the different objects, she is in painting area and takes out a color out of jar and write her name with write hand, she put down green color and picks another marker. She gets up and walks to garden yard, wears her apron ties the laces and ribbons. She is standing by a large soil pot from where other children are getting the soil; she has a soil pot and tries to get the soil from one of a child standing closely. Second boy standing next to her has two scoops she tries to snatch the one because other boy is not letting her have the soil scoop. She snatches a scoop off the boy and cheerfully put some soil into the pot and says put some soil and it will make soil she picks a scoop and presses the soil inside the pot and says I am gonna show my soil and sits next to her teacher, she tries to take wax dough and laughs when her teacher refuses to g ive her the wax dough, teacher parts the dough and gives her half of the dough she smells it pleasingly and kneads it with her hand. Teacher says to her how does it feel? she says good. Teacher says how does it feel like? she says soft and cheerfully shifts the dough from hand to another. She says where is the stick to put it? and leaned forward to get the one and crushes an object on the table, the teacher exclaimed Oops! due sudden movement of Amani, she says she needs sticks and she hold the stick plate and put that near to her and picks the sticks one by one and put them in dough. Teacher says you could sing a song? she says yes and walks to the garden accompanied her teacher after finishing the wax dough, she puts the dough near to flower pots and waters the plants with the help of water shower. Now she is sitting in the garden party table and holding a spoon with plate and pretending to be eating with them. She gets up and leans forward to get another spoon and uses the spoon for picking sugar from the pot and pours into a tea cup and picks another pot, a milk pot and pour it into tea cup to make tea. She again pretends to be eating and her teacher says can you please make me a cup of tea, Maule!? she says with a smile yes, and puts sugar in the cup pleasingly, teacher says again what are you putting? she says with a smile I am putting sugar, and pretends to add more sugar into cup with spoon. She is on the garden party table and eating with spoon and drinking and says I have made it and get off the chair. Now she is in the class and standing next to her teacher who is sitting and singing a poem to children sitting on the floor. She sings the poem Mary with her teacher and classmates. According to Sheila Riddall-Leech (2005), observation is the most effective way to understand about the childs development stages, and its aim is to gather observation base information about a childs progress. Riddall-Leech (2005) further expresses that a single observation is not enough to determine whether or not a child is progressing and improving the developmental skills. Any observation should provide the data necessary to enable a professional to make balanced and informed decisions, such as the planning of specific activities to meet childrens needs, or whether to seek professional help. According to OHagan (2001), it is vital that parents are involved in the childs day to day activities in the school setting. In addition, the parents permission for observing child development is also important in the same regard. Evaluation Physical Development In physical development, Amani is observed for Development of Gross Motor Skills as well as Development of Fine Manipulative Skills (DeRobertis, 2008). Physically Amani is observed and found to be healthy and normal child since she continues to show physical activeness and physical involvement in every activity that a child of four year old is supposed to do such as walking, running, bending, carrying objects, and rolling. During observation, she is found to be physically comfortable of her environment like roaming around without any physical unbalance. She has shown almost all characteristics of Development of Gross Motor Skills. However, she has good physical balance yet at one point she shows lack of balance and co-ordination and control of body like leaning against the table and crushing other objects on the table. Another level of physical development observed is Development of Fine Manipulative Skills (DeRobertis, 2008). Just like every normal child of four year old Amani is ob served to able to using equipment, holding and gripping and drawing, writing and building. She is observed to feel, pouring, filling, touching and exploring dough and building another new object with it. She is observed to using objects like scoop and plant shower very efficiently and using spoon, dressing and using laces and ribbons. Intellectual Development Amani is intellectually observed remarkable as she shows intellect of mind and especially of knowledge and understanding. Both in classroom and play area she is observed as attentive, concentrated, understanding and learning child. The attention and concentration level is highly related to her responsive attitude. She shows some imagining and creativity too, working with wax dough and making cake and pudding of it. She is observed to have knowledge such as answering the teachers questions with her knowledge and writing her own name. The most important intellectuality observed in the Amani is her problem solving tendency such as wearing apron and tying the apron laces herself that shows her intense ability to show problem solving attitude. The sensing and concept formation of Amani is observed in play area where she makes pudding with wax dough, where she is asked about the wax and she responds correctly of the question that wax is soft and it shows great understanding and conceptuali zation of the girl. She seems to show good memory like sugar is added in tea and how to use the eating objects. Her understanding and recognition of objects and colors is extraordinary; she seems to differentiate between a light shade of green and vice versa. Since children learn language and other things by asking questions such as what, where, why, there has been lack of asking questions by Amani, and she intends to respond to the questions rather. Emotional Development Emotionally Amani is observed to be independent as she is able to walk around freely without any hesitation. Moreover, there is no hesitation or difficulty in her expression. She is expressive and good at expressing herself. However, she shows little lack of control over her emotions like when she is in her play area to plant a seed in soil she snatched the scoop from her classmate who refuses to hand her that scoop, though there is not any intense situation yet she looks little out of control of her emotions. Besides, she shows a good emotional balance towards her classmates, she seems to show warm towards her classmate. Facial expression is observed as maturely because she intends to smile all the time whenever she is amused to show her pleasure. She continues to responds the teacher apparently pleasantly and in expressive way. She seems to show good interaction with others but little direct eye contact is observed. The overall body movement and body posture is simply frequently wi thout any hesitancy and normally active and responsive. Tone of voice and play attitude is observed as interactive and sociable involvement. There is such as no sudden change in behavior or language tone. Linguistic Development Amani is observed to have language skills of the level of four year old child. She seems to express herself rather using language. In addition, she is observed to use short sentences and no difficulties and hesitation in speaking. Since language development of child depends on its cognitive skills and Amanis cognitive skills is observed as functioning and efficient, her language fluency and efficiency is improved and better than other children in the classroom. The selection of words and fluency in the speaking is extraordinary good with correct use of tense. Social Development However, Amani is observed as an active, balanced and interactive child yet it has been observed that she has very little double-sided interaction with her classmates. She is observed to interact with her teacher but little is observed her interaction with her classmates. She seems to look warmly and positively but she does not show a productive and cooperative interaction; for example, at one point, she rather snatches the scoop from her classmate rather than making a polite request she seems to behave a little intense. Since, a child of 3 or 4 year is capable of waiting of his/her turn and in normal situation can share and cooperate with fellows (Kail, 2007) therefore it was a little surprising aspect of her because she seems to behave normally so far in other development. In addition, social roles and social behavior like learning appropriately and respond to other is observed normally. However, she seems to enjoy being in classroom with other classmates and enjoy the social appea rance. In regard to other social skills like dressing and moving around without any help and doing different activities she is observed doing them independently. She seems to show a parallel social playing behavior like playing alongside but not with another child, not very much interacting and talking to other children in her different activities. She has been observed as cooperative and with high self-esteem- valuing herself as a person and confident. She rather seems to appear a self-reliance person in social development point of view. Child Profile I observed the child thoroughly and assessed her physically, intellectually, emotionally, linguistically, and socially. The overall development of Amani is observed to be normal and healthy. She has shown normal tendency in all level of development including physical, intellectual, emotional, linguistic and social. However, physical development means doing movement either gross or large movement of limbs or fine manipulative movement of fingers (Grych Fincham, 2001). Amani is found to have large movement of her body and her finger by using pencils and writing. Because physical development mainly depends on the body growth and nervous system that sends message from the brain to body it demonstrates the muscles to motivate them to move. There is great relevance of physical development with intellectual development, because if a child physically not fit or shows problems like little movement, hesitation, and inactive, all these symptoms show inefficient intellectual development of chil d. Amani has been observed as physically active and responsive her intellectual and mental capacity can be assessed as normal and frequent. The intellectual development of Amani is found to be mentally active and interactive along with reasoning mind. She seems to understand the environment, the teachings taught in the classroom and questions asked; she seems to answer them intellectually. She is very attentive and concentrated girl along with ability to respond the external environment. She has good imagining, creative ability and problem solving attitude. Moreover, she possesses an ability to utilize conceptualization of her reality and creativity. Emotionally she is a well balanced child with independent attitude; she has got normal body posture, eye contact, language tone and unchanged behavior. Moreover, her body language and facial expressions are even and warm towards other mates. In linguistic development I observed that she has ability to use language to express her and the re is fluency in the way of her language. Socially she is active, balanced and inter-active child, she is warmly and positive towards interacting towards her mates. She has good learning skills as a social roles and social behavior like learning in a group appropriately. She is socially independent and warm and communicative and responsive. She is expressive, social, cooperative and sharing the things. She has got remarkable cognitive skills and memory power. Different social activities like eating, moving in group and responding; these are those abilities which are extraordinary brought on in her. Common child features of asking questions about the things that they do not know or do not understand, in Amanis case it are bit different in the way that she does not asking question but answering the question rather. Another thing that is important to conclude is her overpowering and strong and intense feeling about her movement. She is intelligent, cooperative, talkative, communicative , and furthermore, creative and imaginative with good self confidence. According to Gambrell (1994) the child who is motivated to learn has many reasons to read and it also includes knowledge gaining, on the other hand Amani is not observed for reading, which can prove her learning motivation. Nevertheless, she is motivated to learning and learning in group which is undermining part of her development.
Sunday, August 4, 2019
Equity and Trust in UK Essay -- fully secret trust, half-secret trust
Consider the validity and effect of the following two clauses in the will of Dan: a) ââ¬ËI leave my cottage, at 42 Drumsesk Road, to my friend Gurpreet in full confidence that he will dispose of it in accordance with the instructions given to him during my lifetimeââ¬â¢. Just before Dan signed the will, he told Gurpreet that he had left a ââ¬Ësum of moneyââ¬â¢ in the will to Gurpreet which he wanted him to hold for the benefit of Jenny. Gurpreet witnessed the will. Jenny died two days before Dan leaving two children. b) ââ¬ËI leave my residuary estate to my brothers Ken and Sam jointlyââ¬â¢. A few days before the execution of the will Dan gave Ken a sealed envelope, saying ââ¬Ëthese are some instructions I want you and Sam to carry out when I dieââ¬â¢. Ken replied ââ¬Ëyou know you can rely on me ââ¬â if itââ¬â¢s fine with Sam itââ¬â¢s fine with meââ¬â¢. A year later Sam and Dan were killed in a car accident. The sealed envelope says that Dan wa nted his residuary estate to pass to his youngest son Joseph. Advise the executors of Danââ¬â¢s will. Secret trust evolved as a response act to the Wills Act 1837 and was originally created to prevent fraud. As the House of Lords held that equity will not allow a statute to be used as an instrument of fraud by the secret trustee . It is a concealed arrangement made between a testator and the trustee and is made to come into force after death. A justification for ST is the ââ¬Ëdehors the willââ¬â¢ theory which means the trusts arise outside of the will - a inter vivos trust. Its purpose is to benefit another individual that hasnââ¬â¢t been written in the formal will. The testator will leave property to the trustee under the will with the understanding that they will hold the property as a gift for which they will then later on be expected to pas... ...y to the real beneficiary. Therefore implying that regardless of Samââ¬â¢s passing away, as Ken had obtained consent on her behalf, before the testator died, the trust will still proceed, and Joseph will obtain Danââ¬â¢s residuary estate. After establishing that this trust is a FST, one must again asses as to whether this trust fulfils all the requirements needed to become binding. Intention was established when Dan gave Ken the sealed envelope with the terms of the trust. Communication was proven when Ken and Dan had an oral conversation in regards to the terms of the trust, Communication was also proven as in Re Keen stated that envelope and letter stating the terms was seen as sufficient amount of communication. Finally acceptance was proven when Ken stated ââ¬Å"you know you can rely on meâ⬠. Concluding that the FST is binding, and Joseph will indeed receive the trust.
The Campaign for Womenââ¬â¢s Suffrage Essay -- American History
The Campaign for Womenââ¬â¢s Suffrage The campaign developed at that time, as it was then the rights of women began to improve. Though women were still thought of as second-class citizens, during the 1870ââ¬â¢s the womenââ¬â¢s suffrage became a mass movement. Prior to 1870, there were laws that meant that women were unable to keep any of their earnings once they married. That also meant that all her possessions belonged to her husband as well. In 1870, the Married Womenââ¬â¢s Property Act meant that women were allowed to keep à £200 of their earnings. Women such as Caroline Norton are what helped the campaign develop. After a court found that she was innocent of adultery, Caroline Nortonââ¬â¢s husband left her and took their children, taking with him her inheritance. Because of the laws at that time, she had no real control over whether she was permitted to see her children, even when one of her sons died. She fought this, even though British law was against her as she was technically the property of her husband. She battled this until in 1873 the law was changed so that all women could see their children if they were divorced from their husband. It was because laws such as this were changed that others began to believe that it was possible to gain the womenââ¬â¢s suffrage. Legal steps were then being taken to better the position of women, legal inequalities that faced women were beginning to then balance out. Another cause to why the womenââ¬â¢s suffrage developed was because of economical reasons. In the late 1800ââ¬â¢s, women were paid half, and sometimes less than half, what men were in the same jobs. For example, in the 1880s in domestic service,... ... peopleââ¬â¢s views on them, it was not the only factor that gave them the franchise. During the war, there was the Coalition Government and members of this were pro-womenââ¬â¢s suffrage. In 1917, the Prime Minister Sir Asquith ââ¬â who was anti-womenââ¬â¢s suffrage ââ¬â resigned. The new PM was Lloyd George, who was actually sympathetic to women receiving the vote. The fact that women had done so much during the war meant that passing the bill was easier that it was before the war. It would have been even unfair if women had done so much during the war, yet they had still not gotten the vote. But there were men that were less qualified and had the vote. This double standard was also a reason. So though the war effort played a part in them receiving the vote, it was not the only reason why women were able to vote once the war had ended.
Saturday, August 3, 2019
Fitzgeralds Exploration of the American Dream in The Great Gatsby Essa
Fitzgerald's Exploration of the American Dream in The Great Gatsby F. Scott Fitzgeraldââ¬â¢s novel, The Great Gatsby, is a one of the best stories written during a chaotic period in our nationââ¬â¢s history, The Jazz Age. The Twenties were a time of social experiments, self-indulgence, and dissatisfaction for majority of Americans. Fitzgerald depicts all these characteristics throughout the novel with his interesting themes, settings, and characters. The most elaborate and symbolic character Fitzgerald presents to his readers is Jay Gatsby. Fitzgerald uses Gatsby as a vehicle to explore the idea of The American Dream, which was a key element in shaping American society and itââ¬â¢s citizens. Fitzgerald does not sugar-coat his definition of the American Dream, but lets his protagonist voice these elements and its decline, challenging the reader to explore the true nature of America in the 1920s. Jay Gatsby, like many average Americans, has a dream of becoming successful and noble. In The Great Gatsby, Jay Gatsby decides to pursue The American Dream as a young adult. Gatsby came from a poor social class, which forced him to work hard even though he would receive no high status in life. Gatsby knew this, but always remained very ambitious and refused to settle for a life of ââ¬Å"janitorââ¬â¢s workâ⬠. It wasnââ¬â¢t until Jay was 17 years old when he found his real inspiration to become successful. Before World War I, Jay Gatsby met Daisy and fell instantly in love with her. Unfortunately for Ga...
Friday, August 2, 2019
Bad Apple Theory
The government has the responsibility of upholding and protecting the rights and welfare of the people. In relation with this, the government established subsidiary bodies and organizations that will help them do their duty of protecting the people. The Police force is among the primary organization that is authorized by the government to maintain the peace and order of their jurisdiction and to properly enforce the law to anyone that will pose a threat to the security of his or her fellow individual or to the general public.However, the reputation of the police force is tainted by corruption due to the illegal practices of some police officers. This kind of problem must be immediately address but there are difficulties in properly controlling corruption because most people still believe with the Bad Apple Theory. The Bad Apple Theory tries to explain the illegal and unethical behavior of some police officers.This theory emphasize that the corrupt practices in the Police Force is due to some ââ¬Å"bad applesâ⬠that are found in a clean barrel. Simply put, this means that corruption is brought about by some bad police officers that are working in a clean and ethical police force. This mentality hinders the proper understanding and control of corruption. Due to the fact, that this Bad Apple Theory is no longer applicable.According to the works of Tim Newburn (1999) entitled: Understanding and preventing police corruption: lessons from the literature, corrupt police officers are not natural-born criminals, nor are they bad men or women who are constitutionally different from their honest co-workers. In order to control corruption, it is essential that the barrel should also be examined and not only the apples. In this sense, the whole organization of the police force should be carefully analyzed to see its flaws that might influence police officers to be corrupt (Newburn, 1999).To be able properly prevent and control corruption in the police force, people sh ould forego of the Bad Apple Theory. Authorities and even ordinary citizen should not only be vigilant with corrupt officers but they should also give due attention to the police fore itself. It must be remembered that ââ¬Å"corrupt police are made, not bornâ⬠(Newburn, 1999). Reference Newburn, T. (1999). Understanding and Preventing Police Corruption: Lessons from the Literature. London: Crown Copyright.
Thursday, August 1, 2019
Titration Curve of Amino Acids
tion Experiment 1 Titration curves of amino acids General structure of amino acids (amphoteric type): Zwitter ion C * : ? ââ¬â carbon : ? ââ¬â amino acid NH2 : ? ââ¬â amino group, basic (proton acceptor) COOH : ? ââ¬â carboxylic group, acidic (proton donor) R : side chain of amino acid Classification of amino acids depending on the nature of side chain: * Neutral * Basic amino acid : with extra amino group (NH2) in its side chain ( histidine, arginine, lysine ) * Acidic amino acid : with extra carboxylic acid group (COOH) in its side chain (aspartic acid & glutamic acid) * With phenol group in its side chain (Tyrosine) * With sulfide group in its side chain (Cysteine) Isoelectric point (pI): It is the pH at which the net charge on the molecule in solution is zero (Zwitter ion). Zwitter ion will not migrate in electric field, it is electrically neutral. pI is the average of the closest values of pKaââ¬â¢s. The pI for the acidic amino acids is the average of pKa1 an d pKa2, while the pI for basic amino acids is the average of pKa2 and pKa3 pKa range for ? COOH ( 1. 71 ââ¬â 2. 63 ) pKa range for ? ââ¬â NH3+ ( 8. 8 ââ¬â 10. 78 ) Acidity of neutral amino acid ? ââ¬â COOH > ? ââ¬â NH3+ For weak acids : Henderson ââ¬â Hasslbalch equation : pH = pKa + log [ A- ] [HA] When [ A- ] = [HA] pH = pKa Acid- base titration: An experiment in which a measured amount of base ( or acid) are added to a measured amount of acid ( or base) to calculate something unknown such as molarity, pHâ⬠¦.. etc.Equivalence point: The point at which an acid is exactly neutralized with a base. Inflection point: The point in an acid- base titration at which 0. 5 mole of base has been added to one mole of acid to achieve [ A- ] = [HA] and then ; pKa = pH Example : Inflection points 0. 5 1 1. 5 2 * Alanine is an example on neutral amino acid which has 2 acidic protons (diprotic acids ) ? ââ¬â COOH and ? ââ¬â NH3+ , these neutral amino acids have t wo titration curves.Net charge +1 0 -1 Zwitter ion Titration curve of Alanine: * aspartic acid is an example on acidic amino acid which has 3 acidic protons (triprotic acids ) ? ââ¬â COOH, ? ââ¬â NH3+ and R- COOH. Acidic amino acids have three titration curves. Acidity of acidic amino acid ? ââ¬â COOH > R- COOH > ? ââ¬â NH3+ Net charge +1 0 -1 -2 Zwitter ionTitration curve of aspartic amino acid * Lysine is an example on basic amino acid which has 3 basic protons (triprotic acids ) ? ââ¬â COOH, ? ââ¬â NH3+ and R- NH3+. Basic amino acids have also three titration curves. Acidity of basic amino acid ? ââ¬â COOH > ? ââ¬â NH3+ > R- NH3+ Net charge +2 +1 0 -1 Zwitter ion Tiration curve of Lysine Method : at low pH ~ 1 ââ¬â 1. 3 amino acid is fully protonated.
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